Supplementary Materials

Supplementary Material for:

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

Suneng Fu, Abdullah Yalcin, Grace Y. Lee, Ping Li, Jason Fan, Ana Paula Arruda, Benedicte M. Pers, Mustafa Yilmaz, Kosei Eguchi, G�khan S. Hotamisligil*

*Corresponding author. E-mail: ghotamis{at}

Published 17 June 2015, Sci. Transl. Med. 7, 292ra98 (2015)
DOI: 10.1126/scitranslmed.aaa9134

This PDF file includes:

  • Fig. S1. Validation of functional reporters.
  • Fig. S2. Effects of azoramide on UPR reporters.
  • Fig. S3. Effects of individual chaperones and UPR sensors on functional reporter activity.
  • Fig. S4. Chaperone overexpression mimics the effect of azoramide pretreatment on ER function.
  • Fig. S5. Azoramide protects against induction of ER stress by tunicamycin.
  • Fig. S6. Long-term azoramide improves glucose metabolism in ob/ob mice.
  • Fig. S7. Synthesis of azoramide.

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