Supplementary Materials

Supplementary Material for:

MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia

Brian C. Evans, Kyle M. Hocking, Michael J. Osgood, Igor Voskresensky, Julia Dmowska, Kameron V. Kilchrist, Colleen M. Brophy, Craig L. Duvall*

*Corresponding author. E-mail: craig.duvall{at}vanderbilt.edu

Published 10 June 2015, Sci. Transl. Med. 7, 291ra95 (2015)
DOI: 10.1126/scitranslmed.aaa4549

This PDF file includes:

  • Methods
  • Fig. S1. Polymer characterization with GPC and NMR.
  • Fig. S2. NP size and morphology.
  • Fig. S3. MK2i uptake and intracellular retention in VSMCs.
  • Fig. S4. MK2i uptake in ECs and effects on EC and VSMC migration.
  • Fig. S5. The effects MK2i-NP and free MK2i on HSV viability.
  • Fig. S6. Viability of MK2i-treated VSMCs used for inflammatory cytokine analysis.
  • Fig. S7. VSMC proliferation assay as a control for migration experiments.
  • Fig. S8. MK2i-NP versus MK2i treatment effects on VSMC and EC MCP-1 production over time.
  • Table S1. NP library characterization.
  • References (3638)

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