Supplementary Materials

Supplementary Material for:

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

Bonnie Huang, Wuhbet D. Abraham, Yiran Zheng, Sandra C. Bustamante López, Samantha S. Luo, Darrell J. Irvine*

*Corresponding author. E-mail: djirvine{at}

Published 10 June 2015, Sci. Transl. Med. 7, 291ra94 (2015)
DOI: 10.1126/scitranslmed.aaa5447

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Em-myc lymphoma cells express homing markers for peripheral lymph nodes, gut, and bone marrow.
  • Fig. S2. T cells expanded in IL-2 with or without rapamycin express similar activation and subset markers.
  • Fig. S3. NCs are synthesized by fusion and covalent stabilization of SN-38–containing liposomes.
  • Fig. S4. T cell transfer alone has no impact on lymphoma progression.
  • Fig. S5. Animals treated with SN-38 therapies show no systemic toxicity.
  • Reference (47)

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