Supplementary Materials

Supplementary Material for:

Drug-induced regeneration in adult mice

Yong Zhang, Iossif Strehin, Khamilia Bedelbaeva, Dmitri Gourevitch, Lise Clark, John Leferovich, Phillip B. Messersmith, Ellen Heber-Katz*

*Corresponding author. E-mail: heberkatz{at}limr.org

Published 3 June 2015, Sci. Transl. Med. 7, 290ra92 (2015)
DOI: 10.1126/scitranslmed.3010228

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Knockdown of Hif1a in B6 and Swiss Webster mouse ear fibroblasts.
  • Fig. S2. Effects of Pluronic F127 on microcrystal growth and stability.
  • Fig. S3. HIF-1α target genes and dedifferentiation marker genes up-regulated by 1,4-DPCA/gel were blocked by knockdown of Hif1a.
  • Fig. S4. HIF-2α is not affected by the 1,4-DPCA drug/gel construct in vitro.
  • Fig. S5. Distal and long-term effects and survival of drug/gel-treated Swiss Webster mice.
  • Fig. S6. Inflammatory responses are affected by 1,4-DPCA treatment.
  • Fig. S7. Synthesis of 1,4-DPCA.
  • Table S1. Primer sequences used for RT-PCR.
  • Table S2. Antibodies used for immunostaining.
  • Table S3. Raw data and statistical significance testing for Fig. 1.
  • Table S4. Raw data and statistical significance testing for Fig. 3G.
  • Table S5. Raw data and statistical significance testing for Fig. 4.
  • Table S6. Raw data and statistical significance testing for Fig. 5.
  • Table S7. Raw data and statistical significance testing for Fig. 6.
  • Table S8. Raw data and statistical significance testing for fig. S5.
  • References (7982)

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