Supplementary Materials

Supplementary Material for:

Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia

Vasyl Holobotovskyy, Yee Seng Chong, Jennifer Burchell, Bo He, Michael Phillips, Leo Leader, Timothy V. Murphy, Shaun L. Sandow, Douglas J. McKitrick, Adrian K. Charles, Marianne Tare, Leonard F. Arnolda, Ruth Ganss*

*Corresponding author. E-mail: ganss{at}

Published 3 June 2015, Sci. Transl. Med. 7, 290ra88 (2015)
DOI: 10.1126/scitranslmed.aaa5038

This PDF file includes:

  • Fig. S1. Diurnal heart rate and genetic background in pregnant RGS5 knockout mice.
  • Fig. S2. Gpcr gene expression during pregnancy.
  • Fig. S3. Peripheral vascular dysfunction in pregnant RGS5 knockout mice.
  • Fig. S4. Oxidative stress and peripheral vascular function in RGS5-deficient mice.
  • Fig. S5. Volume expansion during pregnancy.
  • Fig. S6. Rgs5 gene dose–dependent blood pressure regulation in response to volume expansion.
  • Fig. S7. Placental weight in pregnancies with AngII infusion.
  • Fig. S8. PPAR agonist–mediated improvement of vascular function in HET mice.
  • Fig. S9. Troglitazone treatment and placental phenotype.
  • Table S1. Patient characteristics.

[Download PDF]