Supplementary Materials

Supplementary Material for:

Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury

Sanket S. Acharya, Wojciech Fendler, Jacqueline Watson, Abigail Hamilton, Yunfeng Pan, Emily Gaudiano, Patryk Moskwa, Payel Bhanja, Subhrajit Saha, Chandan Guha, Kalindi Parmar, Dipanjan Chowdhury*

*Corresponding author. E-mail: dipanjan_chowdhury{at}dfci.harvard.edu

Published 13 May 2015, Sci. Transl. Med. 7, 287ra69 (2015)
DOI: 10.1126/scitranslmed.aaa6593

This PDF file includes:

  • Fig. S1. Analysis of peripheral blood CBC parameters after TBI-induced hematopoietic damage.
  • Fig. S2. Repopulation analysis at 1 month after HSC transplant.
  • Fig. S3. Repopulation analysis at 4 months after HSC transplant.
  • Fig. S4. Repopulation analysis after unfractionated whole bone marrow transplant.
  • Fig. S5. Serum miRNA profiling.
  • Fig.S6. miRNAs significantly altered in all irradiated samples.
  • Fig. S7. Radiation dose dependence of select miRNAs.
  • Fig. S8. Identical mature miRNA sequences in human and mouse.
  • Table S1. Peripheral blood CBC levels in individual mice.
  • Table S2. Fold changes of 68 statistically significant miRNAs at different doses of TBI with respect to controls.
  • Table S3. Significantly altered miRNAs between 6.5 and 8 Gy of irradiation and pretreatment with amifostine.
  • Table S4. miRNAs in the 6.5-Gy versus 8-Gy signature as indicators of survival after TBI.
  • Table S5. Percent human CD45+ cell engraftment in individual huCD34+ NSG (humanized) mice.
  • Table S6. Peripheral blood CBC in individual huCD34+ NSG (humanized) mice.
  • Table S7. Target sequences of individual miRNAs.
  • Reference (38)

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