Supplementary Materials

Supplementary Material for:

Dysregulation of astrocyte extracellular signaling in Costello syndrome

Robert Krencik, Kenton C. Hokanson, Aditi R. Narayan, Jill Dvornik, Gemma E. Rooney, Katherine A. Rauen, Lauren A. Weiss, David H. Rowitch, Erik M. Ullian*

*Corresponding author. E-mail: UllianE{at}

Published 6 May 2015, Sci. Transl. Med. 7, 286ra66 (2015)
DOI: 10.1126/scitranslmed.aaa5645

This PDF file includes:

  • Fig. S1. Confirmation of pluripotency and mutant HRAS–induced phenotypes.
  • Fig. S2. Comparison between gene expression up-regulated during HRASWT astrocyte development and induced by HRASG12S.
  • Fig. S3. Numerical data pertaining to Fig. 3A.
  • Fig. S4. Confirmation of transcript dysregulation and drug efficacy.
  • Fig. S5. Numerical data pertaining to Fig. 4C.
  • Fig. S6. In vitro synaptogenesis and characterization of the transgenic mouse model.
  • Fig. S7. Primer pairs used for RT-qPCR.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Microarray data of iPSC astroglial progenitors and astrocytes.
  • Table S2 (Microsoft Excel format). Mass spectrometry data of iPSC ACM.

[Download Tables S1 and S2]