Supplementary Materials

Supplementary Material for:

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

Patrick J. Hanley, Jan J. Melenhorst, Sarah Nikiforow, Phillip Scheinberg, James W. Blaney, Gail Demmler-Harrison, C. Russell Cruz, Sharon Lam, Robert A. Krance, Kathryn S. Leung, Caridad A. Martinez, Hao Liu, Daniel C. Douek, Helen E. Heslop, Cliona M. Rooney, Elizabeth J. Shpall, A. John Barrett, John R. Rodgers, Catherine M. Bollard*

*Corresponding author. E-mail: cbollard{at}cnmc.org

Published 29 April 2015, Sci. Transl. Med. 7, 285ra63 (2015)
DOI: 10.1126/scitranslmed.aaa2546

This PDF file includes:

  • Fig. S1. Identifying atypical epitopes from CMVpp65.
  • Fig. S2. Polyfunctionality of pp65-specific T cells derived from naïve T cells.
  • Fig. S3. Atypical epitope recognition in patient receiving CB-derived virus-specific T cells.
  • Fig. S4. Shared TCRs in the CB-derived virus-specific T cells and patient P2891 6 months after T cell infusion.
  • Table S1. Epitope recognition by CMVneg donors.
  • Table S2. Polyclonality of T cells from CMVneg and CMVpos donors that recognize typical and atypical epitopes.
  • Table S3. Precursor frequencies of TCRs recognizing NLV and MLN from CB.
  • Table S4. Inhibition of CMV dissemination by T cells recognizing typical and atypical epitopes.
  • Source data

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