Supplementary Materials

Supplementary Material for:

Trauma in silico: Individual-specific mathematical models and virtual clinical populations

David Brown, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Joydeep Sarkar, Derek A. Barclay, Jinling Yin, Ali Ghuma, Andrew Abboud, Gregory Constantine, Gary Nieman, Ruben Zamora, Steven C. Chang, Timothy R. Billiar, Yoram Vodovotz*

*Corresponding author. E-mail: vodovotzy{at}

Published 29 April 2015, Sci. Transl. Med. 7, 285ra61 (2015)
DOI: 10.1126/scitranslmed.aaa3636

This PDF file includes:

  • Fig. S1. Sensitivity of damage to IL-6 varies with ISS.
  • Fig. S2. Model-predicted survival trajectories.
  • Table S1. Parameters varied to reproduce patient-level trajectories.
  • Table S2. Observed parameter ranges from individual-level fits.
  • Legend for table S3
  • Appendix 1. Model equations and parameter values.

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Other Supplementary Material for this manuscript includes the following:

  • Table S3. All clinical, demographic, and inflammatory mediator data described in this publication (Excel file).

[Download Table S3]