Supplementary Materials

Supplementary Material for:

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Nicholas McGranahan, Francesco Favero, Elza C. de Bruin, Nicolai Juul Birkbak, Zoltan Szallasi, Charles Swanton*

*Corresponding author. E-mail: charles.swanton{at}

Published 15 April 2015, Sci. Transl. Med. 7, 283ra54 (2015)
DOI: 10.1126/scitranslmed.aaa1408

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Tumor coverage and purity estimates.
  • Fig. S2. Clonal heterogeneity of mutations in specific genes.
  • Fig. S3. High-confidence clonal and subclonal mutations in nine cancer types.
  • Fig. S4. TP53 and genome doubling.
  • Fig. S5. Examples of parallel evolution.
  • Fig. S6. Mutational spectra of clonal and subclonal mutations in cancer genes.
  • Fig. S7. Overall survival and expression of NRXN3.
  • Fig. S8. Clonality of actionable mutations.
  • References (4345)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Driver genes within each cancer type (provided as a separate Excel file).
  • Table S2. Mutational spectra of cancer genes (provided as a separate Excel file).
  • Table S3. Cancer genes identified through clonality and temporal dissection analysis (provided as a separate Excel file).
  • Table S4. Genes linked with targeted therapeutics (provided as a separate Excel file).

[Download Tables S1 to S4]