Supplementary Materials

Supplementary Material for:

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth

Parag Kundu, Maria Genander, Klas Strååt, Johanna Classon, Rachel A. Ridgway, Ee Hong Tan, Jan Björk, Anna Martling, Johan van Es, Owen J. Sansom, Hans Clevers, Sven Pettersson,* Jonas Frisén*

*Corresponding author. E-mail: jonas.frisen{at} (J.F.); sven.pettersson{at} (S.P.)

Published 1 April 2015, Sci. Transl. Med. 7, 281ra44 (2015)
DOI: 10.1126/scitranslmed.3010567

This PDF file includes:

  • Fig. S1. Effect of imatinib on intestinal tumor development and growth.
  • Fig. S2. Effect of blocking EphB signaling on small intestinal adenoma size in ApcMin/+ mice.
  • Fig. S3. Imatinib inhibits PCNA and cyclin D1 in adenomas and reduces tumor volume in nude mice xenografted with Villin CreER Apcfl/lf;p53fl/fl organoids.
  • Table S1. Divergent effects of imatinib on EphB tumor promoter and tumor suppressor signaling pathways.

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