Supplementary Materials

Supplementary Material for:

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy

Everett J. Moding, Katherine D. Castle, Bradford A. Perez, Patrick Oh, Hooney D. Min, Hannah Norris, Yan Ma, Diana M. Cardona, Chang-Lung Lee, David G. Kirsch*

*Corresponding author. E-mail: david.kirsch@duke.edu

Published 11 March 2015, Sci. Transl. Med. 7, 278ra34 (2015)
DOI: 10.1126/scitranslmed.aaa4214

This PDF file includes:

  • Fig. S1. Deletion of Bax in primary tumor endothelial cells does not affect sarcoma initiation or growth.
  • Fig. S2. Deletion of Bax in endothelial cells does not affect sarcoma growth delay after a curative dose of irradiation.
  • Fig. S3. Loss of Bak and Bax in endothelial cells does not affect primary soft tissue sarcoma initiation or growth.
  • Fig. S4. Deletion of Bak and Bax in endothelial cells does not affect primary sarcoma response to radiation therapy.
  • Fig. S5. Deletion of Atm in endothelial cells does not affect sarcoma growth delay after curative doses of irradiation.
  • Fig. S6. Pax7-CreER, but not adeno-Cre, efficiently recombines both AtmFL alleles in primary sarcomas in vivo.
  • Fig. S7. Spectrum of histological responses for primary sarcomas in KPloxPAtmFL/FL mice after irradiation with 50 Gy.
  • Fig. S8. BEZ235 inhibits Atm in primary sarcomas.

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