Supplementary Materials

Supplementary Material for:

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model

Gerhard Leinenga and Jürgen Götz*

*Corresponding author. E-mail:

Published 11 March 2015, Sci. Transl. Med. 7, 278ra33 (2015)
DOI: 10.1126/scitranslmed.aaa2512

This PDF file includes:

  • Methods
  • Fig. S1. Absence of brain damage after either repeated or short-term SUS treatment.
  • Fig. S2. Skeleton analysis of microglia.
  • Fig. S3. Increased Aβ uptake by microglial cells in the presence of albumin.
  • Fig. S4. Analysis of IDE and tau phosphorylation after SUS treatment in AD mice.
  • Fig. S5. Analysis of SUS-treated mice for inflammatory markers.
  • Fig. S6. Absence of astrogliosis but activation of microglia after acute ultrasound treatment in wild-type mice.
  • Legend for movie S1

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). High-resolution 3D reconstruction of a plaque imaged in a 40-μm section of a SUS-treated mouse.

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