Supplementary Materials

Supplementary Material for:

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

Sarah M. Schumacher, Erhe Gao, Weizhong Zhu, Xiongwen Chen, J. Kurt Chuprun, Arthur M. Feldman, John J. G. Tesmer, Walter J. Koch*

*Corresponding author. E-mail:

Published 4 March 2015, Sci. Transl. Med. 7, 277ra31 (2015)
DOI: 10.1126/scitranslmed.aaa0154

This PDF file includes:

  • Detailed Methods
  • Fig. S1. Paroxetine restores βAR mRNA expression.
  • Fig. S2. Paroxetine enhances myocyte contraction in response to ISO in control, but not in βARKct transgenic myocytes.
  • Fig. S3. Paroxetine reduces LV dimension despite elevated GRK2 levels.
  • Fig. S4. Paroxetine’s beneficial effect in post-MI HF is maintained after termination of treatment.
  • Table S1. Reduction of LV dimension by paroxetine is not additive with GRK2 inhibition by βARKct.

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Other Supplementary Material for this manuscript includes the following:

  • Source Data (Excel file)

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