Supplementary Materials

Supplementary Material for:

A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis

Leslie W. Chan, Xu Wang, Hua Wei, Lilo D. Pozzo, Nathan J. White,* Suzie H. Pun*

*Corresponding author. E-mail: spun@uw.edu (S.H.P.); whiten4@uw.edu (N.J.W.)

Published 4 March 2015, Sci. Transl. Med. 7, 277ra29 (2015)
DOI: 10.1126/scitranslmed.3010383

This PDF file includes:

  • Materials and Methods
  • Fig. S1. TEG measurements for fibrinogen and plasmin titration study.
  • Fig. S2. In vitro comparison of PolySTAT to PolySCRAM and component controls.
  • Fig. S3. TEG measurements for hemodilutions.
  • Fig. S4. PT in rat femoral artery injury models.
  • Fig. S5. Fibrinogen concentration in rat femoral artery injury models.
  • Fig. S6. MAP in rat femoral artery injury models.
  • Fig. S7. Lactate concentration of rat femoral artery injury models.
  • Table S1. Comprehensive metabolic and hepatic function panel results for 1 hour, 1 day, and 1 week after PolySTAT injection in rats.
  • Table S2. Pharmacokinetic constants for PolySTAT.
  • Table S3. PolySTAT content in urine after tail vein injection.
  • Movie S1. Lysis of control fibrin formed with PBS.
  • Movie S2. Lysis of control fibrin formed with PolySCRAM.
  • Movie S3. Lysis of PolySTAT-modified fibrin.
  • Movie S4. Lysis of hFXIIIa cross-linked fibrin.

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1. Lysis of control fibrin formed with PBS.
  • Movie S2. Lysis of control fibrin formed with PolySCRAM.
  • Movie S3. Lysis of PolySTAT-modified fibrin.
  • Movie S4. Lysis of hFXIIIa cross-linked fibrin.

[Download Movies S1 to S4]