Supplementary Materials

Supplementary Material for:

A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis

Leslie W. Chan, Xu Wang, Hua Wei, Lilo D. Pozzo, Nathan J. White,* Suzie H. Pun*

*Corresponding author. E-mail: spun@uw.edu (S.H.P.); whiten4@uw.edu (N.J.W.)

Published 4 March 2015, Sci. Transl. Med. 7, 277ra29 (2015)
DOI: 10.1126/scitranslmed.3010383

This PDF file includes:

Materials and Methods
Fig. S1. TEG measurements for fibrinogen and plasmin titration study.
Fig. S2. In vitro comparison of PolySTAT to PolySCRAM and component controls.
Fig. S3. TEG measurements for hemodilutions.
Fig. S4. PT in rat femoral artery injury models.
Fig. S5. Fibrinogen concentration in rat femoral artery injury models.
Fig. S6. MAP in rat femoral artery injury models.
Fig. S7. Lactate concentration of rat femoral artery injury models.
Table S1. Comprehensive metabolic and hepatic function panel results for 1 hour, 1 day, and 1 week after PolySTAT injection in rats.
Table S2. Pharmacokinetic constants for PolySTAT.
Table S3. PolySTAT content in urine after tail vein injection.
Movie S1. Lysis of control fibrin formed with PBS.
Movie S2. Lysis of control fibrin formed with PolySCRAM.
Movie S3. Lysis of PolySTAT-modified fibrin.
Movie S4. Lysis of hFXIIIa cross-linked fibrin.

Other Supplementary Material for this manuscript includes the following: