Supplementary Materials

Supplementary Material for:

Learning to identify CNS drug action and efficacy using multistudy fMRI data

Eugene P. Duff,* William Vennart, Richard G. Wise, Matthew A. Howard, Richard E. Harris, Michael Lee, Karolina Wartolowska, Vishvarani Wanigasekera, Frederick J. Wilson, Mark Whitlock, Irene Tracey, Mark W. Woolrich, Stephen M. Smith

*Corresponding author. E-mail: eugene.duff{at}

Published 11 February 2015, Sci. Transl. Med. 7, 274ra16 (2015)
DOI: 10.1126/scitranslmed.3008438

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Alternative clinical efficacy procedure.
  • Fig. S2. Modeling of pain responses in the pregabalin study b (24).
  • Fig. S3. Summary of significant effects in individual study placebo versus drug pain response contrasts for individual analgesic studies in Table 2.
  • Table S1. Results of procedure applied to analgesic studies when experimental stimuli with lower clinical relevance are used.
  • Table S2. Outcome of the analgesic assessment protocol when using inputs derived from a set of pain-related ROIs.
  • References (3539)

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