Supplementary Materials

Supplementary Material for:

Protein-releasing polymeric scaffolds induce fibrochondrocytic differentiation of endogenous cells for knee meniscus regeneration in sheep

Chang H. Lee, Scott A. Rodeo, Lisa Ann Fortier, Chuanyong Lu, Cevat Erisken, Jeremy J. Mao*

*Corresponding author. E-mail: jmao{at}columbia.edu

Published 10 December 2014, Sci. Transl. Med. 6, 266ra171 (2014)
DOI: 10.1126/scitranslmed.3009696

This PDF file includes:

  • Fig. S1. Fibrochondrogenic differentiation of human bone marrow MSCs in 3D fibrin.
  • Fig. S2. Fibrochondrogenic matrix production by fibrochondrocytes derived from human MSCs in monolayer culture.
  • Fig. S3. Fibrochondrogenic matrix production by fibrochondrocytes derived from human MSCs in 3D fibrin gel.
  • Fig. S4. FAK and p38 signaling plays a role in collagen and aggrecan expression after fibrochondrocyte differentiation in vitro.
  • Fig. S5. Single-cell progenies of human bone marrow MSCs differentiate into fibrochondrocytes.
  • Fig. S6. Mechanical testing of scaffold to meniscus and partially resected meniscus.
  • Table S1. Fibrochondrocyte differentiation from human bone marrow MSCs in monolayer and 3D cultures.
  • Table S2. Statistical significances for comparisons in between groups in Fig. 1 and fig. S2.
  • Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.wmv format). Sheep movement after medial meniscus replacement with 3D-printed scaffold with spatial CTGF and TGFβ3 delivery.
  • Movie S2 (.wmv format). Sheep movement after medial meniscus replacement with 3D-printed scaffold with empty μS.

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