Supplementary Materials

Supplementary Material for:

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

Yan Liu, Aarti Asnani, Lin Zou, Victoria L. Bentley, Min Yu, You Wang, Graham Dellaire, Kumar S. Sarkar, Matthew Dai, Howard H. Chen, David E. Sosnovik, Jordan T. Shin, Daniel A. Haber, Jason N. Berman, Wei Chao, Randall T. Peterson*

*Corresponding author. E-mail: rtpeterson{at}

Published 10 December 2014, Sci. Transl. Med. 6, 266ra170 (2014)
DOI: 10.1126/scitranslmed.3010189

This PDF file includes:

  • Fig. S1. VIS and DPU do not decrease ROS levels.
  • Legends for movies S1 to S3

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Movie S1. (DMSO.m4v): Heart contraction of 3-dpf zebrafish treated with vehicle (1% DMSO in E3 water).
  • Movie S2. (DOX.m4v): Heart contraction of 3-dpf zebrafish treated with 100 μM Dox.
  • Movie S3. (DOX + VIS.m4v): Heart contraction of 3-dpf zebrafish cotreated with Dox (100 μM) and VIS (20 μM).

[Download Movies S1 to S3]