Supplementary Materials

Supplementary Material for:

Prediction of resistance development against drug combinations by collateral responses to component drugs

Christian Munck, Heidi K. Gumpert, Annika I. Nilsson Wallin, Harris H. Wang, Morten O. A. Sommer*

*Corresponding author. E-mail: msom{at}

Published 12 November 2014, Sci. Transl. Med. 6, 262ra156 (2014)
DOI: 10.1126/scitranslmed.3009940

This PDF file includes:

  • Fig. S1. Fold increase in drug tolerance during evolution experiment.
  • Fig. S2. IC90 dose-response curves.
  • Fig. S3. Correlation between IC50 or MIC, and IC90-based measurements.
  • Fig. S4. Alternative correlation between FICI and evolution of resistance.
  • Fig. S5. Competition between wild-type ΔlacZ and mutant.
  • Table S1. Raw OD600 readings.
  • Table S2. Sequencing coverage.
  • Table S3. Individual SNPs and INDELs.
  • Table S4. Oligos for MAGE and qPCR primers.
  • Reference (76)

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