Supplementary Materials

Supplementary Material for:

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

Antonio DiGiandomenico, Ashley E. Keller, Cuihua Gao, Godfrey J. Rainey, Paul Warrener, Mareia M. Camara, Jessica Bonnell, Ryan Fleming, Binyam Bezabeh, Nazzareno Dimasi, Bret R. Sellman, Jamese Hilliard, Caitlin M. Guenther, Vivekananda Datta, Wei Zhao, Changshou Gao, Xiang-Qing Yu, JoAnn A. Suzich, C. Kendall Stover*

*Corresponding author. E-mail: stoverk{at}medimmune.com

Published 12 November 2014, Sci. Transl. Med. 6, 262ra155 (2014)
DOI: 10.1126/scitranslmed.3009655

This PDF file includes:

  • Table S1. P. aeruginosa strain survey for Psl, PcrV, exoU, and exoS.
  • Table S2. Determination of MICs.
  • Fig. S1. Isobologram analysis for synergistic activity.
  • Fig. S2. BiS4αPa treatment protects mice from lethal pneumonia.
  • Fig. S3. BiS4αPa reduces P. aeruginosa organ burden.
  • Fig. S4. BiS4αPa opsonophagocytic killing activity against P. aeruginosa clinical isolates.
  • Fig. S5. BiS4αPa anti-cytotoxic activity against P. aeruginosa clinical isolates.
  • Fig. S6. BiS4αPa protection in P. aeruginosa lethal challenge models.

[Download PDF]