Supplementary Materials

Supplementary Material for:

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Y. Joy Yu, Jasvinder K. Atwal, Yin Zhang, Raymond K. Tong, Kristin R. Wildsmith, Christine Tan, Nga Bien-Ly, Maria Hersom, Janice A. Maloney, William J. Meilandt, Daniela Bumbaca, Kapil Gadkar, Kwame Hoyte, Wilman Luk, Yanmei Lu, James A. Ernst, Kimberly Scearce-Levie, Jessica A. Couch, Mark S. Dennis, Ryan J. Watts*

*Corresponding author. E-mail: rwatts{at}

Published 5 November 2014, Sci. Transl. Med. 6, 261ra154 (2014)
DOI: 10.1126/scitranslmed.3009835

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Generation and characterization of a human TfR knock-in mouse model.
  • Fig. S2. In vitro and in vivo characterization of TfR degradation related to species and affinity.
  • Fig. S3. PD analysis in monkey after anti-TfR/BACE1 antibody dosing.

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