Supplementary Materials

Supplementary Material for:

Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention

Martin Bergstrand,* Fran├žois Nosten, Khin Maung Lwin, Mats O. Karlsson, Nicholas J. White, Joel Tarning

*Corresponding author. E-mail: martin.bergstrand{at}

Published 29 October 2014, Sci. Transl. Med. 6, 260ra147 (2014)
DOI: 10.1126/scitranslmed.3005311

This PDF file includes:

  • Table S1. Descriptive statistics for study population baseline characteristics.
  • Fig. S1. Illustration of covariate relationship between age (years) and the probability of belonging to the low-hazard population (PMIX2).
  • Fig. S2. Illustration of the relationship between parasite count at the time of diagnosis and the approximated event censoring interval.
  • Text file. NONMEM output file: Pharmacokinetics.
  • Text file. NONMEM output file: Pharmacokinetics-Pharmacodynamics.

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