Supplementary Materials

Supplementary Material for:

PCSK9 is a critical regulator of the innate immune response and septic shock outcome

Keith R. Walley,* Katherine R. Thain, James A. Russell, Muredach P. Reilly, Nuala J. Meyer, Jane F. Ferguson, Jason D. Christie, Taka-aki Nakada, Chris D. Fjell, Simone A. Thair, Mihai S. Cirstea, John H. Boyd

*Corresponding author. E-mail: keith.walley{at}

Published 15 October 2014, Sci. Transl. Med. 6, 258ra143 (2014)
DOI: 10.1126/scitranslmed.3008782

This PDF file includes:

  • Methods
  • Table S1. Physiological response of mice to LPS.
  • Table S2. Allele frequency and Hardy-Weinberg equilibrium in VASST cohort.
  • Table S3. Baseline characteristics of patients by PCSK9 LOF and GOF genotype.
  • Table S4. Logistic regression. LOF and GOF effects on 28-day survival in septic shock cohorts.

[Download PDF]