Supplementary Materials

Supplementary Material for:

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

S. Armando Villalta,* Wendy Rosenthal, Leonel Martinez, Amanjot Kaur, Tim Sparwasser, James G. Tidball, Marta Margeta, Melissa J. Spencer, Jeffrey A. Bluestone

*Corresponding author. E-mail: avillalta{at}

Published 15 October 2014, Sci. Transl. Med. 6, 258ra142 (2014)
DOI: 10.1126/scitranslmed.3009925

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Increased leukocytes in mdx dystrophic muscle.
  • Fig. S2. Splenomegaly, lymphadenopathy, and increased cellularity in mdx mice.
  • Fig. S3. Tregs are elevated in mdx diaphragm muscle.
  • Fig. S4. Tconvs are activated in dystrophic muscle.
  • Fig. S5. Anti-CD25 antibody-mediated depletion of Tregs in mdx mice.
  • Fig. S6. Specific ablation of Tregs in mdxDEREG mice.
  • Fig. S7. Sustained Treg ablation in mdxFoxP3.DTR-KI mice.
  • Fig. S8. The histological features of control and dystrophic muscle biopsies.
  • Table S1. Characteristics of the control and DMD/BMD patients used for histological examination.
  • Table S2. T cell counts in human patients.

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