Supplementary Materials

Supplementary Material for:

Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia

David N. Bochner, Richard W. Sapp, Jaimie D. Adelson, Siyu Zhang, Hanmi Lee, Maja Djurisic, Josh Syken, Yang Dan, Carla J. Shatz*

*Corresponding author. E-mail: cshatz{at}

Published 15 October 2014, Sci. Transl. Med. 6, 258ra140 (2014)
DOI: 10.1126/scitranslmed.3010157

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Example line scan measurements of Arc mRNA in situ hybridization signal in visual cortex induced by stimulation of the ipsilateral eye.
  • Fig. S2. Plasticity indices for genetic or pharmacological disruption of PirB function.
  • Fig. S3. Characterization of sPirB minipump infusion area and effect on OD plasticity.
  • Fig. S4. Effect of minipump infusions of sPirB or BSA on dendritic spines by cells and by spine type.

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