Supplementary Materials

Supplementary Material for:

IL-32 is a molecular marker of a host defense network in human tuberculosis

Dennis Montoya, Megan S. Inkeles, Phillip T. Liu, Susan Realegeno, Rosane M. B. Teles, Poorva Vaidya, Marcos A. Munoz, Mirjam Schenk, William R. Swindell, Rene Chun, Kathryn Zavala, Martin Hewison, John S. Adams, Steve Horvath, Matteo Pellegrini, Barry R. Bloom, Robert L. Modlin*

*Corresponding author. E-mail:

Published 20 August 2014, Sci. Transl. Med. 6, 250ra114 (2014)
DOI: 10.1126/scitranslmed.3009546

This PDF file includes:

  • Fig. S1. Expression of IL-32 in adherent PBMC microarray.
  • Fig. S2. IFN-γ–induced DDX60 expression is unchanged by siIL15 knockdown.
  • Fig. S3. IL-32 induction of CYP27b1 is dose-dependent.
  • Fig. S4. IFN-γ–induced TLR7 expression is unchanged by siIL-32 knockdown.
  • Fig. S5. Common genes expressed in latent TB.
  • Fig. S6. IL-32 higher in latent TB patients versus patients with sarcoidosis.
  • Fig. S7. IL-32 and IFN-γ expression after treatment with MVA85a vaccine.
  • Fig. S8. Role of IL-32 in host defense.
  • Table S1. Top hub genes of IL15black defense response network.
  • Table S2. Myeloid genes correlated with IL-32 in the IL-15 defense response functional cluster.
  • Table S3. TB data sets used in this study.

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Other Supplementary Material for this manuscript includes the following:

  • Table S4. Original data used for graphs (provided as separate Excel file).

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