Supplementary Materials

Supplementary Material for:

Genetic validation of a therapeutic target in a mouse model of ALS

A. Sophie de Boer, Kathryn Koszka, Evangelos Kiskinis, Naoki Suzuki, Brandi N. Davis-Dusenbery, Kevin Eggan*

*Corresponding author. E-mail:

Published 6 August 2014, Sci. Transl. Med. 6, 248ra104 (2014)
DOI: 10.1126/scitranslmed.3009351

This PDF file includes:

  • Materials and Methods
  • Fig. S1. DP1 plays a role in glial toxicity to motor neurons.
  • Fig. S2. Characterization of DP1 mutant glia.
  • Fig. S3. Characterization of DP1 mutant compound animals.
  • Fig. S4. Characterization of inflammatory markers in DP1 mutant compound animals.
  • Fig. S5. M1 and M2 microglial activation.
  • Fig. S6. Human glial characterization.

[Download PDF]