Supplementary Materials

Supplementary Material for:

Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus

Xiang-ni Wu, Yan-xia Ye, Jing-wen Niu, Yang Li, Xin Li, Xin You, Hua Chen, Li-dan Zhao, Xiao-feng Zeng, Feng-chun Zhang, Fu-lin Tang, Wei He, Xue-tao Cao, Xuan Zhang,* Peter E. Lipsky*

*Corresponding author. E-mail: (X.Z.); (P.E.L.)

Published 23 July 2014, Sci. Transl. Med. 6, 246ra99 (2014)
DOI: 10.1126/scitranslmed.3009131

This PDF file includes:

  • Fig. S1. Unlike IL-21, anti-IgM plus CD40L did not induce miR-7 up-regulation.
  • Fig. S2. B cells from NZB/NZW F1 lupus mice expressed high levels of miR-7.
  • Fig. S3. Time course of the expression of PTEN RNA and protein as well as miR-7 expression in HC B cells after stimulation with IL-21.
  • Fig. S4. si-PTEN transfection knocked down PTEN expression in B cells.
  • Fig. S5. Gating controls for flow cytometry experiments.
  • Table S1. Raw data for Fig. 1.
  • Table S2. Raw data for Fig. 4A.
  • Table S3. Raw data for Fig. 7B.
  • Table S4. Raw data for Fig. 7C.

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