Supplementary Materials

Supplementary Material for:

Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients

Kenneth E. Sherman,* Jeremie Guedj, Mohamed Tarek Shata, Jason T. Blackard, Susan D. Rouster, Mario Castro, Judith Feinberg, Richard K. Sterling, Zachary Goodman, Bruce J. Aronow, Alan S. Perelson

*Corresponding author. E-mail:

Published 23 July 2014, Sci. Transl. Med. 6, 246ra98 (2014)
DOI: 10.1126/scitranslmed.3008195

This PDF file includes:

  • Fig. S1. HIV RNA viral clearance in response to ART treatment.
  • Fig. S2. Spearman correlation (two-tailed) between HIV viral kinetic parameters.
  • Fig. S3. Correlation between HIV viral kinetic parameters and changes in HCV RNA at different time points.
  • Fig. S4. Correlation between HIV viral kinetic parameters and maximal reductions in HCV RNA from baseline during the first 4 weeks of treatment.
  • Fig. S5. Strong HCV-specific immune responses in co-infected patients who experienced ALT flare or rebound HCV viral load after ART initiation.
  • Fig. S6. Biological network analysis of gene functions and regulatory relationships among genes whose expression increased or decreased after cART.
  • Table S1. Results of Granger causality analysis for HIV RNA and HCV RNA using data until day 7.
  • Table S2. Top 50 overall most differentially regulated genes after treatment versus baseline.

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