Supplementary Materials

Supplementary Material for:

Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease

Sam C. Nalle, H. Aimee Kwak, Karen L. Edelblum, Nora E. Joseph, Gurminder Singh, Galina F. Khramtsova, Eric D. Mortenson, Peter A. Savage,* Jerrold R. Turner*

*Corresponding author. E-mail: jturner@bsd.uchicago.edu (J.R.T.); psavage@bsd.uchicago.edu (P.A.S.)

Published 2 July 2014, Sci. Transl. Med. 6, 243ra87 (2014)
DOI: 10.1126/scitranslmed.3008941

This PDF file includes:

  • Fig. S1. Typical lung histopathology develops during minor mismatch GVHD.
  • Fig. S2. Bone marrow is not required for minor mismatch GVHD.
  • Fig. S3. Tight junction–associated proteins are redistributed after irradiation and minor mismatch AT.
  • Fig. S4. Rag2−/−/Pfp−/− recipients of mismatch AT develop features of GVHD.
  • Fig. S5. Major mismatch AT is associated with increases in serum cytokines.
  • Fig. S6. NK cell depletion and intestinal damage promote AT-induced GVHD histopathology.
  • Fig. S7. Minor mismatch donor cells show substantial proliferation regardless of pretransplant treatment.
  • Fig. S8. Perforin-deficient mice receiving allogeneic AT develop pulmonary GVHD.
  • Fig. S9. Pretransplant conditioning makes dual contributions to minor mismatch GVHD.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S1. Original data (provided as an Excel file).