Supplementary Materials

Supplementary Material for:

Parallel Discovery of Alzheimer's Therapeutics

Andrew W. Lo,* Carole Ho, Jayna Cummings, Kenneth S. Kosik

*Corresponding author. E-mail:

Published 18 June 2014, Sci. Transl. Med. 6, 241cm5 (2014)
DOI: 10.1126/scitranslmed.3008228

This PDF file includes:

  • Introduction
  • Computing Expected Returns and Variances
  • IID Bernoulli Trials
  • Correlated Trials
  • Fig. S1. Probability of success
  • Simulating Correlated Bernoulli Trials
  • Fig. S2. Heat-map of pairwise correlations
  • Fig. S3. Heat-map of positive-definite correlation matrix
  • Megafund Investment Performance
  • Table S1. AD projects and success
  • Table S2. Returns
  • Cost/Benefit Analysis
  • Table S3. Trajectories
  • Table S4. Medicare and Medicaid cost savings

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