Supplementary Materials

Supplementary Material for:

Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

Angeliki Asimaki, Sudhir Kapoor, Eva Plovie, Anne Karin Arndt, Edward Adams, ZhenZhen Liu, Cynthia A. James, Daniel P. Judge, Hugh Calkins, Jared Churko, Joseph C. Wu, Calum A. MacRae, André G. Kléber, Jeffrey E. Saffitz*

*Corresponding author. E-mail:

Published 11 June 2014, Sci. Transl. Med. 6, 240ra74 (2014)
DOI: 10.1126/scitranslmed.3008008

This PDF file includes:

  • Materials and Methods
    Fig. S1. Gal4/UAS-based expression system and chemical screen protocol in zebrafish.
  • Fig. S2. No change in IKr current density in ventricular myocytes from controls and mutant fish at 3 to 4 weeks of age.
  • Fig. S3. Double-label immunohistochemistry showing colocalization of Cx43 and N-cadherin signals at the cell surface.
  • Fig. S4. Decreased INa and IK1 current density in neonatal rat ventricular myocytes expressing 2057del2 plakoglobin, and rescue by SB216763.
  • Fig. S5. Abnormal distribution of SAP97 in myocardium of patients with ACM.
  • Fig. S6. Derivation of hiPSC and iPSC-derived cardiac myocytes.
  • References (36, 37)

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