Supplementary Materials

Supplementary Material for:

Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

Jeremy L. Pinyon, Sherif F. Tadros, Kristina E. Froud, Ann C. Y. Wong, Isabella T. Tompson, Edward N. Crawford, Myungseo Ko, Renée Morris, Matthias Klugmann, Gary D. Housley*

*Corresponding author. E-mail:

Published 23 April 2014, Sci. Transl. Med. 6, 233ra54 (2014)
DOI: 10.1126/scitranslmed.3008177

This PDF file includes:

  • Materials and Methods
    Fig. S1. Micro-computed tomography of the guinea pig skull showing the cochlear implant array.
  • Fig. S2. Characterization of the guinea pig cochlear sensory epithelium degeneration after ototoxic treatment.
  • Fig. S3. Acoustically evoked ABRs to click stimuli in guinea pigs before and after ototoxic treatment.
  • Fig. S4. β-Tubulin immunofluorescence in cryosections demonstrating BDNFmediated regeneration of spiral ganglion neurites in deafened guinea pig cochleae.
  • Table S1. Nuclear GFP-labeled mesenchymal cell counts arising from ex vivo cochlear CFE gene delivery.
  • Table S2. GFP+ transfected mesenchymal cells after CFE in vivo.
  • Reference (41)

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