Supplementary Materials

Supplementary Material for:

Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

Amy W. Chung, Musie Ghebremichael, Hannah Robinson, Eric Brown, Ickwon Choi, Sophie Lane, Anne-Sophie Dugast, Matthew K. Schoen, Morgane Rolland, Todd J. Suscovich, Alison E. Mahan, Larry Liao, Hendrik Streeck, Charla Andrews, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Mark S. de Souza, Jaranit Kaewkungwal, Punnee Pitisuttithum, Donald Francis, Nelson L. Michael, Jerome H. Kim, Chris Bailey-Kellogg, Margaret E. Ackerman, Galit Alter*

*Corresponding author. E-mail: galter@partners.org

Published 19 March 2014, Sci. Transl. Med. 6, 228ra38 (2014)
DOI: 10.1126/scitranslmed.3007736

This PDF file includes:

  • Fig. S1. Differences between RV144 and VAX003 Fc-mediated Ab functions.
  • Fig. S2. Fc-effector functions correlate between gp120MN and gp120A244 for both vaccine trials.
  • Fig. S3. Ab Fc-function correlation differences between RV144 and VAX003.
  • Fig. S4. Antigen-specific IgG subclass correlations for RV144 and VAX003 samples.
  • Fig. S5. Correlation of Fc-effector function from bulk and IgG3- and IgG4- depleted RV144 and VAX003 samples.
  • Fig. S6. Evolving relationship between VAX003 gp120-specific IgG subclass and ADCP.
  • Fig. S7. Differential binding of RV144 and VAX003 bulk purified IgG samples to Fcg receptors.
  • Fig. S8. gp120MN-specific IgG binding over time.

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