Supplementary Materials

Supplementary Material for:

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease

Anne M. Fagan,* Chengjie Xiong, Mateusz S. Jasielec, Randall J. Bateman, Alison M. Goate, Tammie L. S. Benzinger, Bernardino Ghetti, Ralph N. Martins, Colin L. Masters, Richard Mayeux, John M. Ringman, Martin N. Rossor, Stephen Salloway, Peter R. Schofield, Reisa A. Sperling, Daniel Marcus, Nigel J. Cairns, Virginia D. Buckles, Jack H. Ladenson, John C. Morris, David M. Holtzman, The Dominantly Inherited Alzheimer Network

*Corresponding author. E-mail:

Published 5 March 2014, Sci. Transl. Med. 6, 226ra30 (2014)
DOI: 10.1126/scitranslmed.3007901

This PDF file includes:

  • Table S1. Comparison of estimated mean plasma biomarker concentrations between NCs and MCs at defined EYO.
  • Table S2. Comparison of estimated mean CSF biomarker concentrations and cognitive performance between NCs and MCs at defined EYO.
  • Table S3. Estimated mean (SE) annual within-individual rate of change in CSF biomarkers and a psychometric composite score in NCs and MCs in (A) unadjusted analyses and (B) analyses adjusted for gender and APOE genotype.
  • Fig. S1. Mean (SE) % CVs in analyte measures between longitudinal samples obtained from a given individual (black) compared to within a given sample run in duplicate (white).
  • Fig. S2. Evaluation of psychometric test performance in NCs and MCs in the longitudinal cohort.

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