Supplementary Materials

Supplementary Material for:

Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun–Regulated Macrophage Activation

Michael T. Beste, Nicole Pfäffle-Doyle, Emily A. Prentice, Stephanie N. Morris, Douglas A. Lauffenburger, Keith B. Isaacson, Linda G. Griffith*

*Corresponding author. E-mail: griff@mit.edu

Published 5 February 2014, Sci. Transl. Med. 6, 222ra16 (2014)
DOI: 10.1126/scitranslmed.3007988

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Sample size estimation and power calculations.
  • Fig. S2. Multiplex immunoassay performance.
  • Fig. S3. NMF of randomized and reduced data sets.
  • Fig. S4. Peritoneal aspirate characteristics across molecular subpopulations.
  • Fig. S5. Isolation and relative cytokine secretion of adherent peritoneal macrophages.
  • Fig. S6. Differential cytokine secretion by peritoneal macrophages.
  • Fig. S7. Enrichment analysis of ASRM III/IV cytokines.
  • Fig. S8. Inferred coexpression of ASRM III/IV cytokines.
  • Table S1. Pairwise Wilcoxon rank-sum tests—treatment status.
  • Table S2. Pairwise Wilcoxon rank-sum tests—ASRM staging.
  • Table S3. Pairwise Wilcoxon rank-sum tests—cycle phase.
  • Table S4. Pairwise Wilcoxon rank-sum tests—recurrence status.
  • Table S5. Pairwise Wilcoxon rank-sum tests—lesion distribution.
  • Table S6. Pairwise Wilcoxon rank-sum tests—primary indication.
  • Table S7. Reported associations between peritoneal cytokines, chemokines, growth factors, and pelvic endometriosis.
  • Table S8. Overrepresented transcriptional binding sites among macrophagesecreted cytokines.
  • Table S9. Luminex targets and assay performance characteristics.
  • Table S10. Leukocyte subpopulations among peritoneal aspirates.
  • Table S11. Kinase inhibitor treatments.
  • Reference (39)

[Download PDF]