Supplementary Materials

Supplementary Material for:

Antioxidants Accelerate Lung Cancer Progression in Mice

Volkan I. Sayin, Mohamed X. Ibrahim, Erik Larsson, Jonas A. Nilsson, Per Lindahl,* Martin O. Bergo*

*Corresponding author. E-mail: martin.bergo@gu.se (M.O.B.); per.lindahl@wlab.gu.se (P.L.)

Published 29 January 2014, Sci. Transl. Med.6, 221ra15 (2014)
DOI: 10.1126/scitranslmed.3007653

This PDF file includes:

  • Fig. S1. Antioxidant supplementation increases tumor stage in mice with BRAFV600E–induced lung cancer.
  • Fig. S2. Administration of antioxidants to mice with K-RASG12D–induced lung cancer reduces tumor expression of endogenous antioxidant genes.
  • Fig. S3. NAC and vitamin E reduce ROS and DNA damage and increase tumor cell proliferation.
  • Fig. S4. Antioxidants do not affect the amounts of apoptotic and senescent cells in tumors of mice with K-RASG12D– and B-RAFV600E–induced lung cancer.
  • Fig. S5. NAC and Trolox increase the proliferation of fibroblasts expressing oncogenic, but not wild-type, K-RAS and B-RAF.
  • Fig. S6. Antioxidants increase the proliferation of MYC-transformed fibroblasts.
  • Fig. S7. Antioxidants increase the proliferation of human lung cancer cell lines expressing wild-type p53.
  • Fig. S8. TP53 is required for antioxidants to increase the proliferation of human lung cancer cell lines.
  • Reference (41)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1. Original data (Excel spreadsheet).
  • Table S2. Exact P values (Excel spreadsheet).

[Tables S1 and S2 ]