Supplementary Materials

Supplementary Material for:

Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks

Slavenka Kam-Hansen, Moshe Jakubowski, John M. Kelley, Irving Kirsch, David C. Hoaglin, Ted J. Kaptchuk, Rami Burstein*

*Corresponding author. E-mail: rburstei@bidmc.harvard.edu

Published 8 January 2014, Sci. Transl. Med.6, 218ra5 (2014)
DOI: 10.1126/scitranslmed.3006175

This PDF file includes:

  • Methods
  • Scripted Information Read to Participants
  • Randomization of Treatment and Treatment Labeling
  • Missing Data
  • Analyses of Primary Endpoint—Fitting the Main Model
  • Analyses of Secondary Endpoint
  • Table S1. Reasons for excluding 19 of the prescreened subjects.
  • Table S2. Background characteristics of participants and dropouts.
  • Table S3. Selected quantiles of nondichotomous background characteristics of the 66 participants.
  • Table S4. Incidence of missing pain scores and data imputation.
  • Table S5. Structure of the eight treatment sequences and assignment of subjects to treatment sequences.
  • Table S6. Distribution of attacks with imputed pain scores and pain freedom at 2.5 hours.
  • Table S7. Estimates of parameters in the main model for the pain scores including the imputed pain scores at 2.5 hours.
  • Table S8. Percentage decrease in the estimated average pain score from 30 min to 2.5 hours under the seven experimental conditions (from an analysis that included imputed pain scores at 2.5 hours).
  • Table S9. Estimates of parameters in the covariate model for the pain scores including the imputed pain scores at 2.5 hours.
  • Table S10. Estimates of difference (2.5 hours minus 30 min) on the primary endpoint for key contrasts involving treatment and labeling.
  • Table S11. Sensitivity analysis of the main model for the pain scores.
  • Table S12. Estimates of parameters in the main model for pain freedom at 2.5 hours.
  • Table S13. Estimated probability of being pain-free 2 hours after treatment under the seven experimental conditions (from an analysis that included imputed pain scores at 2.5 hours).
  • Table S14. Estimates of difference (2.5 hours minus 30 min) on the secondary endpoint for key contrasts involving treatment and labeling.

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