Supplementary Materials

Supplementary Material for:

CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy

Alberto K. De la Herrán-Arita, Birgitte Rahbek Kornum, Josh Mahlios, Wei Jiang, Ling Lin, Tieying Hou, Claudia Macaubas, Mali Einen, Gi seppe Plazzi, Catherine Crowe, Evan W. Newell, Mark M. Davis, Elizabeth D. Mellins,* Emmanuel Mignot*

*Corresponding author. E-mail: mignot{at} (E.M.); mellins{at} (E.D.M.)

Published 18 December 2013, Sci. Transl. Med. 5, 216ra176 (2013)
DOI: 10.1126/scitranslmed.3007762

This PDF file includes:

  • Fig. S1. CD4+ T cell TNF-α response to DQ0602 strong binding peptides.
  • Fig. S2. T cell response to HCRT epitopes with different APCs.
  • Fig. S3. ROC curves for ELISpot data.
  • Fig. S4. DQ0602 binding of HCRT and pHA1 peptides with amino acid substitutions.
  • Fig. S5. Binding of pH1N1 peptides to DQ0602.
  • Fig. S6. Possible mimics of HCRT epitopes in pH1N1 stimulate T cells from narcoleptic patients and controls.
  • Fig. S7. Representative ELISpot images corresponding to Figs. 4 and 6.
  • Table S1. Prepro-HCRT peptides showing binding to DQ0602.
  • Table S2. pHA1 peptides showing binding to DQ0602.
  • Table S3. pNA1 peptides showing binding to DQ0602.
  • Table S4. pPB1 peptides showing binding to DQ0602.
  • Table S5. Influenza A H1N1 strains used for vaccinations by year.
  • Reference (48)

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