Supplementary Materials

Supplementary Material for:

HIV-1 Vpr Induces Adipose Dysfunction in Vivo Through Reciprocal Effects on PPAR/GR Co-Regulation

Neeti Agarwal, Dinakar Iyer, Sanjeet G. Patel, Rajagopal V. Sekhar, Terry M. Phillips, Ulrich Schubert, Toni Oplt, Eric D. Buras, Susan L. Samson, Jacob Couturier, Dorothy E. Lewis, Maria C. Rodriguez-Barradas, Farook Jahoor, Tomoshige Kino, Jeffrey B. Kopp, Ashok Balasubramanyam*

*Corresponding author. E-mail: ashokb{at}

Published 27 November 2013, Sci. Transl. Med. 5, 213ra164 (2013)
DOI: 10.1126/scitranslmed.3007148

This PDF file includes:

  • Fig. S1. Plasma Vpr levels in mice injected with sVpr.
  • Fig. S2. Expression of adiponectin and aP2 in PGF and IF of Vpr-Tg.
  • Fig. S3. Gating strategy for flow cytometry.
  • Fig. S4. Vpr does not block differentiation genes in 3T3-L1 72 hours after differentiation induction.
  • Fig. S5. Hyperglycemia and hypertriglyceridemia in Vpr-Tg.
  • Fig. S6. Paracrine effect of Vpr.
  • Table S1. Vpr in human liver and adipose tissue.
  • Table S2. Palmitate flux in a second line of Vpr-Tg.
  • Table S3. Twenty-four–hour calorimetry.
  • Table S4. Mouse weight and food intake in Vpr-Tg and sVpr-treated mice.
  • Table S5. Primer sequences for ChIP qPCR.
  • Reference (49)

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