Supplementary Materials

Supplementary Material for:

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

Eloise Hudry, Jonathan Dashkoff, Alysson D. Roe, Shuko Takeda, Robert M. Koffie, Tadafumi Hashimoto, Maria Scheel, Tara Spires-Jones, Michal Arbel-Ornath, Rebecca Betensky, Beverly L. Davidson, Bradley T. Hyman*

*Corresponding author. E-mail: bhyman@mgh.harvard.edu

Published 20 November 2013, Sci. Transl. Med. 5, 212ra161 (2013)
DOI: 10.1126/scitranslmed.3007000

This PDF file includes:

  • Fig. S1. Detection of human and endogenous murine APOE mRNA and protein after intracerebroventricular injection of AAV4-APOE in APP/PS1 mice.
  • Fig. S2. Effects on Aβ pathology associated with each ApoE isoform after a short exposure (2 months).
  • Fig. S3. No change in APP processing and glial cell recruitment around amyloid deposits upon expression of different ApoE isoforms.
  • Fig. S4. Changes in soluble and insoluble Aβ species detected 3 months after injection in Tg2576 mice.

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