Supplementary Materials

Supplementary Material for:

Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

Feyza Engin, Alena Yermalovich, Truc Nguyen, Sarah Hummasti, Wenxian Fu, Decio L. Eizirik, Diane Mathis, Gökhan S. Hotamisligil*

*Corresponding author. E-mail: ghotamis@hsph.harvard.edu

Published 13 November 2013, Sci. Transl. Med. 5, 211ra156 (2013)
DOI: 10.1126/scitranslmed.3006534

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Specific alterations of the UPR mediators in the islets of NOD mice.
  • Fig. S2. Specific alterations of Glut2 and Keap1 expression in the islets of NOD mice.
  • Fig. S3. Dysregulation of the molecules critical in the UPR in the islets of male T1D patients.
  • Fig. S4. Immunophenotyping of splenocytes of NOD mice after TUDCA treatment.
  • Fig. S5. Immunophenotyping of pancreatic lymph nodes of NOD mice after TUDCA treatment.
  • Fig. S6. Deletion of ATF6 branch of the UPR in β cells in vivo.

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