Supplementary Materials

Supplementary Material for:

SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure

Lisa Tilemann, Ahyoung Lee, Kiyotake Ishikawa, Jaume Aguero, Kleopatra Rapti, Carlos Santos-Gallego, Erik Kohlbrenner, Kenneth M. Fish, Changwon Kho, Roger J. Hajjar*

*Corresponding author. E-mail: roger.hajjar@mssm.edu

Published 13 November 2013, Sci. Transl. Med. 5, 211ra159 (2013)
DOI: 10.1126/scitranslmed.3006487

This PDF file includes:

  • Methods
  • Fig. S1. Cardiac function parameters before MI creation and 1 month after MI in pigs.
  • Fig. S2. Effect of SUMO-1 gene transfer on cardiac proteins.
  • Fig. S3. Coronary gene delivery does not harm liver and kidney tissues.
  • Fig. S4. Serum chemistries 3 months after MI.
  • Fig. S5. Vector copy numbers of AAV1.SUMO-1 in various tissues and tissue distribution of SUMO-1 expression 3 months after MI.
  • Legends for movies S1 to S4

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.avi format). 3D echocardiogram of a representative animal in the SUMO-1 high-dose group at 1 month.
  • Movie S2 (.avi format). 3D echocardiogram of a representative animal in the SUMO-1 high-dose group at 3 months.
  • Movie S3 (.avi format). 3D echocardiogram of a representative animal in the saline group at 1 month.
  • Movie S4 (.avi format). 3D echocardiogram of a representative animal in the saline group at 3 months.

[Movies S1 to S4]