Supplementary Materials

Supplementary Material for:

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Brian Finan, Tao Ma, Nickki Ottaway, Timo D. Müller, Kirk M. Habegger, Kristy M. Heppner, Henriette Kirchner, Jenna Holland, Jazzminn Hembree, Christine Raver, Sarah H. Lockie, David L. Smiley, Vasily Gelfanov, Bin Yang,Susanna Hofmann, Dennis Bruemmer, Daniel J. Drucker, Paul T. Pfluger, Diego Perez-Tilve, Jaswant Gidda, Louis Vignati, Lianshan Zhang, Jonathan B. Hauptman, Michele Lau, Mathieu Brecheisen, Sabine Uhles, William Riboulet, Emmanuelle Hainaut, Elena Sebokova, Karin Conde-Knape, Anish Konkar, Richard D. DiMarchi,* Matthias H. Tschöp*

*Corresponding author. E-mail: rdimarch@indiana.edu (R.D.D.); tschoep@helmholtzmuenchen.de (M.H.T.)

Published 30 October 2013, Sci. Transl. Med. 5, 209ra151 (2013)
DOI: 10.1126/scitranslmed.3007218

This PDF file includes:

  • Fig. S1. Sequences of native hormones and engineered analogs.
  • Fig. S2. Indirect calorimetry analysis in DIO mice.
  • Fig. S3. Pair-feeding comparison in DIO mice.
  • Fig. S4. Genomic profile of white adipose tissue, liver, and quadriceps.
  • Fig. S5. Comparison in GLP-1RKO mice.
  • Fig. S6. Effects on hepatic damage and steatosis in DIO mice.
  • Fig. S7. Effects on glycemia and islet cytoarchitecture in ZDF rats.

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