Supplementary Materials

Supplementary Material for:

A Human Type 5 Adenovirus–Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti- Adenovirus Immunity

Fiona Smaill, Mangalakumari Jeyanathan, Marek Smieja, Maria Fe Medina, Niroshan Thanthrige-Don, Anna Zganiacz, Cindy Yin, Armando Heriazon, Daniela Damjanovic, Laura Puri, Jemila Hamid, Feng Xie, Ronan Foley, Jonathan Bramson, Jack Gauldie, Zhou Xing*

*Corresponding author. E-mail:

Published 2 October 2013, Sci. Transl. Med. 5, 205ra134 (2013)
DOI: 10.1126/scitranslmed.3006843

This PDF file includes:

  • Fig. S1. Persistently raised T cell reactivity to AdHu5Ag85A vaccination.
  • Fig. S2. Activation of polyfunctional CD4 and CD8 T cell subsets in BCG and BCG+ human subjects by AdHu5Ag85A vaccination.
  • Fig. S3. Lack of CD8 T cell responsiveness to M.tbCF stimulation in vaccinated BCG and BCG+ subjects.
  • Fig. S4. Lack of significant correlation between the magnitude of T cell activation after AdHu5Ag85A vaccination and preexisting anti-AdHu5 total IgG antibody titers.
  • Table S1. Demographic details of enrolled trial volunteers.

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