Supplementary Materials

Supplementary Material for:

Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development

Lejla Imamovic and Morten O. A. Sommer*

*Corresponding author. E-mail: msom@bio.dtu.dk

Published 25 September 2013, Sci. Transl. Med. 5, 204ra132 (2013)
DOI: 10.1126/scitranslmed.3006609

This PDF file includes:

  • Table S1. Drug adaptation level and clinical breakpoints.
  • Table S2. Drug common use.
  • Table S3. List of possible collateral sensitivity cycles.
  • Fig. S1. MIC inhibition curves for E. coli MG1655 resistant strains and WT.
  • Fig. S2. Competition assay.
  • Fig. S3. Collateral sensitivity and collateral resistance distribution.
  • Fig. S4. MIC inhibition curves for E. coli EC3770 resistant strains and WT.
  • Fig. S5. MIC inhibition curves for E. coli EC3856 resistant strains and WT.

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