Supplementary Materials

Supplementary Material for:

Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48

Elias Pavlopoulos, Sidonie Jones, Stylianos Kosmidis, Maggie Close, Carla Kim, Olga Kovalerchik, Scott A. Small,* Eric R. Kandel*

*Corresponding author. E-mail: erk5@columbia.edu (E.R.K.); sas68@columbia.edu (S.A.S.)

Published 28 August 2013, Sci. Transl. Med. 5, 200ra115 (2013)
DOI: 10.1126/scitranslmed.3006373

This PDF file includes:

  • Fig. S1. Specificity of the microdissections from human postmortem tissue.
  • Fig. S2. Anxiety in mice expressing the dominant-negative inhibitor of RbAp48 in their forebrain.
  • Fig. S3. Anxiety of wild-type mice tested in hippocampal-dependent memory tasks.
  • Fig. S4. Data from the Morris water maze that complement Fig. 4.
  • Fig. S5. Noncognitive parameters from the Morris water maze of DT mice and control littermates tested off doxycycline.
  • Fig. S6. Noncognitive parameters from the Morris water maze of DT mice and control littermates tested on doxycycline.
  • Fig. S7. Noncognitive parameters from the Morris water maze of young and aged wild-type mice.
  • Fig. S8. Effect of lentivirus-mediated up-regulation of RbAp48 in the DG of aged wild-type mice on age-related loss of hippocampus-dependent memory.
  • Fig. S9. RbAp48 effect on the protein levels of CBP.
  • Table S1. Comparative studies of histone acetylation.
  • Table S2. Oligonucleotides used for RNA in situ hybridization and PCR cloning.
  • Table S3. Detailed statistical analysis of behavioral, biochemical, and immunohistochemical studies.
  • Reference (50)

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