Supplementary Materials

Supplementary Material for:

Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy

Francesca Mascia, Gary Lam, Christopher Keith, Caroline Garber, Seth M. Steinberg, Elise Kohn, Stuart H. Yuspa*

*Corresponding author. E-mail:

Published 21 August 2013, Sci. Transl. Med. 5, 199ra110 (2013)
DOI: 10.1126/scitranslmed.3005773

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Epidermal differentiation markers and total CD45 protein in WT and KO skin.
  • Fig. S2. Epidermal differentiation markers and CD45-positive leukocytes in mouse skin lacking EGFR.
  • Fig. S3. Supernatants of cultured keratinocytes and macrophage chemotaxis.
  • Fig. S4. Time course analysis of cytokine and chemokine changes in mouse skin after epidermal EGFR ablation.
  • Fig. S5. Macrophage depletion and KO skin phenotype.
  • Table S1. Bacteria detected on mouse skin.
  • Table S2. Demographic characteristics of the patients involved in the study.
  • Table S3. P values of data highlighted as significant with asterisks.

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Other Supplementary Material for this manuscript includes the following:

  • Table S4. Individual data values (Excel file).

[Table S4]