Supplementary Material

Supplementary Material for:

Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

Federico Sandoval, Magali Terme, Mevyn Nizard, Cécile Badoual, Michel-Francis Bureau, Ludovic Freyburger, Olivier Clement, Elie Marcheteau, Alain Gey, Guillaume Fraisse, Cécilia Bouguin, Nathalie Merillon, Estelle Dransart, Thi Tran, Françoise Quintin-Colonna, Gwennhael Autret, Marine Thiebaud, Muhammad Suleman, Sabine Riffault, Tzyy-Choou Wu, Odile Launay, Claire Danel, Julien Taieb, Jennifer Richardson, Laurence Zitvogel, Wolf H. Fridman, Ludger Johannes, Eric Tartour*

*To whom correspondence should be addressed. E-mail:

Published 13 February 2013,, Sci. Transl. Med. 5, 172ra20 (2013)
DOI: 10.1126/scitranslmed.3004888

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Intranasal STxB-based vaccines target mediastinal DCs.
  • Fig. S2. Intranasal immunization with STxB induces multifunctional antigenspecific CD8+ T cells.
  • Fig. S3. STxB-E7 combined with CpG is efficient to inhibit mucosal tumor growth in a therapeutic setting.
  • Fig. S4. CD4+ T cell and NK infiltration in mice vaccinated by STxB-E7 by the intranasal route.
  • Fig. S5. Lung DCs induce the expression of CD49a on CD8+ T cells.
  • Fig. S6. TC1 cells do not express E-cadherin.
  • Fig. S7. Detection of specific IgA response in the BAL and vaginal lavage after intranasal immunization with STxB-OVA.

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