Supplementary Materials

Supplementary Material for:

α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

Mickael Decressac,* Banafsheh Kadkhodaei, Bengt Mattsson, Ariadna Laguna, Thomas Perlmann, Anders Björklund*

*To whom correspondence should be addressed. E-mail: Anders.Bjorklund{at}med.lu.se (A.B.); Mickael.Decressac{at}med.lu.se (M.D.)

Published 5 December 2012, Sci. Transl. Med. 4, 163ra156 (2012)
DOI: 10.1126/scitranslmed.3004676

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Trophic response induced by intrastriatal injection of human GDNF in nigral DA neurons.
  • Fig. S2. Expression of GDNF and a-synuclein, GFP transgene expression, and survival of nigral DA neurons.
  • Fig. S3. α-Synuclein overexpression represses transcriptional activity in DA neurons.
  • Fig. S4. IGF-1 signaling is preserved in DA neurons overexpressing α-synuclein.
  • Table S1. List of RT-qPCR primers.

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